EFFECT OF SAPPAN WOOD (Caesalpinnia sappan L) EXTRACT ON BLOOD GLUCOSE LEVEL IN WHITE RATS

Autor(s): Saefudin Saefudin, Gunawan Trisandi Pasaribu, Sofnie Sofnie, Efrida Basri
DOI: 10.20886/ijfr.2014.1.2.109-115

Abstract

Sappan wood or kayu secang (Caesalpinia sappan L.) was reported of having medicinal properties, such as natural antioxidant, relieve vomiting of blood, and mix of ingredients for malaria drugs. The research was conducted to study the influence of ethanol extract from sappan wood on blood glucose level of white rats. The study of the blood glucose level in rats was carried out by using glucose tolerance method. It was measured by Refloluxs (Accutrend GC) with Chloropropamide 50 mg/200 g BW (Body weight) as positive control. The ethanol extracts were used in various concentrations 10, 20, 30, 40 and 50 mg/200 g BW per-oral and was observed every hour, beginning one hour before to 7 hours after the extract being administered. The results showed that treatment of ethanol extract of sappan wood by administer doses gave remarkable effect on the blood glucose level in white rat. It reduced the glucose level in the blood compared to the negative and positive control. Treatment of dose 30 mg/200 g BW gave similar effect to positive controls, while a dose of 50 mg/200 g BW gave lower blood glucose level (93 mg/dl) than the positive controls.

Keywords

Sappan wood; ethanol extract; blood glucose level; white rat

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References

Amrun, M., & Umiyah. (2005). Pengujian antiradikal bebas Difenilpikril Hidrazil (DPPH) ekstrak buah kenitu (Chrysophyllum cainito L.) dari daerah sekitar Jember. Jurnal Ilmu Dasar, 6(2), 110–114.

Aulia, F. X. (2002). ). Stabilitas zat warna kayu secang (Caesalpinia sappan Linn.) terhadap suhu dan pH (Skripsi). Universitas Islam Negeri.

Badami, S., Moorkoth, S., Rai, S. R., Elango, L., & Bhojraj, S. (2003). Antioxidant activity of Caesalpinia sappan heartwood. Biol. Pharm. Bulletin, 26(11), 1534 – 1537.

Badami, S., Moorkoth, S., & Suresh, B. (2004). Caesalpinia sappan a medical and dye yielding plant. Natural Products Radiance, 3(2), 75–82.

Chairul. (2003). Identifikasi secara cepat bahan bioaktif pada tumbuhan di lapangan. Berita Biologi, 6(4), 621–629.

Hakim, E. H., Syah, Y. ., Juliawati, L. D., & Mujahidin, D. (2008). Aktivitas antioksidan dan inhibitor tirosinase beberapa stilbenoid dari tumbuhan Moraceae dan Dipterocarpaceae yang potensial untuk bahan kosmetik. Jurnal Matematika Dan Sains, 13(2), 33–42.

Jafri, M. ., Aslam, M., Javed, K., & Singh, S. (2000). Effect of Punica granatum Linn. (flowers) on blood glucose level in normal and alloxan-induced diabetic rats. Journal of Ethnopharmacology, 70, 309–314.

Malole, M. B. M., & Purnomo, C. S. U. (n.d.). Buku panduan penggunaan hewan-hewan percobaan di laboratorium Institut Pertanian Bogor (p. 94). Bogor.

Pranoto, G. (1999). Potensi dan strategi industrilisasi obat tradisional Indonesia, dalam Seminar Nasional Pendayagunaan Potensi Obat Tradisional Indonesia sebagai Unsur dalam Sistem Kesehatan (p. 86). Jakarta: BPPT.

Praptiwi, Harapini, M., & Astuti, I. (2006). Nilai peroksida Aglaia argentea Blume, A. silvestria (M. Roemer) Merr., dan A. tomentosa Teijsm. & Binn. Biodiversitas, 7(3), 242–244.

Prawirosujanto, S. (1977). Materia medika Indonesia (pp. 63–70). Jakarta: Depkes RI.

Rohman, A., Riyanto, S., & Utari, D. (2006). Aktivitas antioksidan, kandungan fenolik total dan kandungan flavonoid total ekstrak etil asetat buah mengkudu serta fraksi-fraksinya. Majalah Farmasi Indonesia, 17(3), 136–142.

Sudjana. (1982). Disain dan analisis eksperimen (pp. 18–40). Bandung: Tarsito.

Sugati, S. (1981). Inventarisasi tanaman obat Indonesia (pp. 90–91). Jakarta: Balitbangkes Depkes RI.

Takaoka, M., & Tagakaki, Y. (1995). Effect of the crude drugs on β-hexosaminidase release from rat basophilic leukemia (RBL-2H3) cells. Nat. Med, 49(3), 346–349.

Walujo, E. B. (2008). Review: Research ethnobotany in indonesia and the future perspectives. Jurnal Biodiversitas, 9(1), 59–63.

World Conservation Monitoring Centre. (1998). Caesalpinia sappan. IUCN Red List of Threatened Species. Version 2009. Retrieved February 11, 2010, from http://www.iucnredlist.org/

Xu, H.-X., & Lee, S. F. (2004). The antibacterial principle of Caesalpina sappan. Phytother. Res., 18, 647–651.

You, E. J., Khil, L. Y., Kwak, W. J., Won, H. S., Chae, S. H., Lee, B. H., & Moon, C. K. (2005). Effects of brazilin on the production of fructose-2,6-bisphosphate in rat hepatocytes. Journal of Ethnopharmacology, 102(1), 53–57.

DOI: https://doi.org/10.20886/ijfr.2014.1.2.109-115

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